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Zopiclone
Zopfresh

  • Amoban / Imozop / Zimovane / Zopinox
  • SLE005
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per pill is $14.58 ! Buying from us will save you at least 34.22%

Package per pill Price SAVINGS BONUS Order
20mg * 30 pills
$9.59 $287.70 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
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►Next orders 10% discount
20mg * 60 pills
$5.76 $345.60 $229.80
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
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►Free 10 bonus pills
20mg * 90 pills
$4.98 $448.20 $414.90
+ GOLD BONUS
GOLD BONUS
for orders between $300 & $550
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►Next orders 10% discount
►Free 10 bonus pills
20mg * 120 pills
$4.81 $577.20 $573.60
+ PLATINUM BONUS
PLATINUM BONUS
for orders over $550
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►Next orders 15% discount
►Free standard airmail service
►VIP Personalized Offers
20mg * 180 pills
$3.79 $682.20 $1,044.00
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PLATINUM BONUS
for orders over $550
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►Next orders 15% discount
►Free standard airmail service
►VIP Personalized Offers

For the short-term treatment of insomnia.

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate like properties.

It is used to help people with sleeping difficulties, also called insomnia. It can help you fall asleep and to reduce the number of times you wake up during the night. It is used for short term treatment (2-4 weeks) of insomnia. It is not recommended for use for more than 4 weeks at a time.

Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia.

While Zopiclone is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex.

Subunit modulation of the GABABZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models.

Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor.

Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex.

Both zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on α1, α2, α3 and α5 GABAA containing receptors as full agonists causing an enhancement of the inhibitory actions of GABA to produce the therapeutic (hypnotic and anxiolytic) and adverse effects of zopiclone.

Metabolism: Extensively metabolized in the liver via decarboxylation (major pathway), demethylation, and side chain oxidation. Metabolites include an N-oxide derivative (weakly active; approximately 12% of a dose) and an N-desmethyl metabolite (inactive; approximately 16%). Approximately 50% of a dose is converted to other inactive metabolites via decarboxylation. Hepatic microsomal enzymes are apparently not involved in zopiclone clearance.

Absorption: Rapidly absorbed following oral administration.

Half life: Elimination half life is approximately 5 hours (range 3.8 to 6.5 hours) and is prolonged to 11.9 hours in patients with hepatic insufficiency.

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Zopiclone.

Tell your doctor or pharmacist if you have any medical conditions.

Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agent. Signs and symptoms of overdose effects of CNS depressants can be expected to present as exaggerations of the pharmacological effects noted in preclinical testing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Claire
16/May/2024

Great to put you and keep you asleep. Can still wake up for a pee in middle of night, lye back down and you're gone until you wake in the morning. I rate it best sleep tablet I have ever had. Good prices too...

Brian
27/Apr/2024

Been taking this drug as a sleep aid and need two 7.5mg to fall asleep, but it get's the job done very well with no bad side effects the next day. I just wish that it last a full 7 or 8 hours, four to five hours seems to be the norm. But it's still alot better than alot of other sleep aids that Iv'e tried over the last few months.

Lindsey
19/Apr/2024

I went through a stage of strong depression and I believe this medication saved my life! One night I couldn't cope with my feelings and was in a hysterical state. I took a tablet and automatically started calming down and got sleepy- I finally had a good night sleep since then. I might have woke up once or twice in the night but was still sleepy so managed to get back to sleep. On the bad night I woke up about four hours later and took another half pill. They recommend taking one or two max per day. If anyone is ever suffering like I did take one. Lack of sleep does crazy things to people and my state of mind has increasingly improved since starting this course and through my strong depression, I knew it wouldn't last through the night; I had something to help me cope. If you are prescribed this, it is definitely worth a go. Takes about half an hour for me to start calming down on it and within the hour I'm definitely ready for bed! Good luck!

Yolanda
06/Apr/2024

I have taken Zopiclone every now and then for my chronic insomnia. It is very effective in getting me to sleep but it doesn't keep me asleep. On Zopiclone I sleep for around 4 to 5 hours and then wake up but I usually can get back to sleep. After about 20 mins of taking Zopiclone I begin to feel its effects, when I stand up I feel my limbs getting heavy and sort of a drunk feeling but it's a pleasant feeling at the same time. I then go to bed and I usually fall asleep almost instantly afterwards, it certainly knocks me out. Overall it's an effective drug for getting to sleep but don't be surprised if it doesn't keep you asleep for 7 or 8 hours. But it is very effective if you take a long time to fall asleep.

Gertrude
01/Apr/2024

In my head, I've always associated anxiety with social nerves and inactivity. Zopiclone is, for me, a miracle cure because, after just 15 minutes, I genuinely feel calmer and I'm no longer scared of meeting my neighbors, etc. With the zopis I've also got back my desire to go outside. I take them in the morning once I'm awake for depression, 1 at 12 noon so I can go outside and in the evening so I can relax and watch TV. The difficult thing is that I don't sleep during the day but at least my head is quiet!!!

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